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Abstract #2445

Cerebral Blood Flow of CASL Perfusion Imaging to Predict Neurobehavioral Outcome in a Murine Model of Subarachnoid Hemorrhage

Kazumasu Sasaki1,2, Tatsushi Mutoh2,3, Kazuhiro Nakamura2,3, Tomoko Mutoh3,4, Yasuko Tatewaki3, Tomoyuki Yambe1, Yasuyuki Taki3, and Tatsuya Ishikawa2

1Department of Preclinical Evaluation, Institute of Development, Aging and Cancer (IDAC), Tohoku University, Sendai, Japan, 2Research Institute for Brain and Blood Vessels-AKITA, Akita, Japan, 3Department of Nuclear Medicine and Radiology, IDAC, Tohoku University, Sendai, Japan, 4Graduate School of Psychology, Kobe Shoin Women’s University, Kobe, Japan

Early brain injury/ischemia is a recent therapeutic target of subarachnoid hemorrhage (SAH) that contributes to triggering delayed cerebral ischemia (DCI) [1]. However, little is known about the role of cerebral blood flow (CBF) and neurobehavioral profiles at acute stage on functional outcome of the rodent model to simulate clinical severity early after SAH. The present study demonstrated the feasibility of MRI-based CBF measurements using the continuous arterial spin labeling (CASL) perfusion images for precise grading of the severity in a murine model of endovascular perforation model of SAH.

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