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Abstract #2442

Excitatory Repetitive Transcranial Magnetic Stimulation (rTMS) Induces Contralesional Cortex-Cerebellar Pathways to Facilitate Motor Recovery after Acute Ischemic Stroke

Jing Li1, Zhentao Zuo2, Xuewei Zhang1,3, Jie Lu1, Xiali Shao1, Rong Xue2, Yong Fan4, Yuzhou Guan5, and Weihong Zhang1

1Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, People's Republic of China, 2State Key Laboratory of Brain and Cognitive Science, Beijing MR Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, People's Republic of China, 3Department of Interventional Radiology, China Meitan General Hospital, Beijing, People's Republic of China, 4Department of Radiology, Department of Radiology, School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, 5Department of Neurology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, People's Republic of China

In this study we used the Diffusion Tensor Imaging method to assess motor pathway changes in acute ischemic stroke patients after high frequency repetitive transcranial magnetic stimulation (rTMS). We found that the excitatory rTMS applied to the ipsilesional primary motor cortex induced the contralesional cortex-cerebellar loop to facilitate motor recovery. The result is consistent with those of our former studies and gives us a clue to understand the therapeutic mechanism of rTMS for early stroke patients.

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