Abstract #2431

Microstructural alterations in patients after liver transplantation and treated with calcineurin inhibitors – a quantitative MRI study

Lukas Goede¹, Birte Schmitz¹, Henning Pflugrad², Anita Blanka Tryc², Hannelore Barg-Hock³, Jürgen Klempnauer³, Karin Weissenborn², Heinrich Lanfermann¹, and Xiao-Qi Ding¹

¹Institute for Neuroradiology, Hannover Medical School, Hannover, Germany, ²Department of Neurology, Hannover Medical School, Hannover, Germany, ³Clinic for Visceral and Transplant Surgery, Hannover Medical School, Hannover, Germany

With the aim to evaluate possible brain microstructural alterations associated with calcineurin inhibitor (CNI) therapy, ninety patients after liver transplantation (OLT) treated with different doses of CNI and 32 gender- and age-adjusted healthy volunteers were studied with quantitative MRI (qMRI). T1, T2, T2*, Proton density (PD) and phase changes (derived from susceptibility-weighted imaging, SWI) were measured in 18 brain regions (regions of interest, ROIs). The values were compared between the groups of patients and the controls, which showed significant differences between the groups, indicating alterations of brain microstructure in patients after OLT.

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