Problem: The quantification accuracy of myelin water fraction mapping based on multi echo spin echo (MESE) T2 relaxometry is compromised due to high SNR requirement, along with the need to account for contributions from stimulated echo pathways.
Methods: A novel expectation-maximization post-processing method, with convergence guaranty, is proposed, which accounts for stimulated contributions intrinsically, while simultaneously improving noise robustness by utilizing spatial correlation from 3D local neighborhood.
Results & Conclusions: Results demonstrate improved quantifications as a result of the proposed algorithm.
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