Abstract #2418

Altered microstructural integrity in patients with tuberous sclerosis complex revealed by whole-brain tract-specific analysis

Chien-Feng Huang¹, Chih-Hsien Tseng^1,2, Pi-Chuan Fan³, and Wen-Yih Isaac Tseng^1,2,4

¹Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan, ²)Institute of Biomedical Engineering, National Taiwan University College of Medicine, Taipei, Taiwan, ³Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, ⁴Molecular Imaging Center, National Taiwan University, Taipei, Taiwan

To investigate whether the white matter tracts are altered in patients with tuberous sclerosis complex, we used whole-brain tract-specific analysis of diffusion spectrum imaging (DSI) data to measure the alteration of 76 major white matter tracts, and compared the property between 27 patients and 27 matched controls. As compared to the controls, patients showed significantly lower GFA in 13 tracts. The altered microstructural integrity of the white matter tracts in TSC supports the hypothesis of underlying microstructural changes in the brains of TSC.

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