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Abstract #2396

Imaging of thalamic calcium deposits due to sports-related concussion using Quantitative Susceptibility Mapping (QSM)

Ferdinand Schweser1,2, Deepa P Ramasamy1, Jesper Hagemeier1, Barry Willer3, Nicola Bertolino1, Dhaval Shah1, David J Poulsen4, John Leddy5, and Robert Zivadinov1,2

1Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, 2MRI Clinical and Translational Research Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, 3Department of Psychiatry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, 4Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, 5Department of Orthopaedics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States

This work explored the hypothesis that the activation of N-methyl-D-aspartate (NMDA)-receptors in the thalamus results in persistent calcium deposits after a sports-related concussion that can be visualized clinically with Quantitative Susceptibility Mapping at 3 Tesla. The study involved 22 retired professional contact-sports athletes and 45 controls. We found a significantly higher incidence of thalamic micro-calcifications in contact-sports athletes compared to controls, in particular in ice hockey players.

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Abstract