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Abstract #2393

A Repetitive Traumatic Brain Injury Model Characterized with Diffusion Tensor and Diffusion Kurtosis Imaging with Neuropathological Correlation

Fengshan Yu1,2, Dinesh K. Shukla3, Christina M. Marion2, Kryslaine L. Radomski1,2, Reed G. Selwyn4, Regina C. Armstrong1,2, and Bernard J. Dardzinski1,5

1Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States, 2Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States, 3Department of Psychiatry, University of Maryland School of Medicine at Baltimore, Baltimore, MD, 4Radiology, University of New Mexico, Albuquerque, NM, United States, 5Radiology and Radiological Sciences, Uniformed Services University of the Health Sciences, Bethesda, MD

Mild traumatic brain injury (mTBI) often involves single (s-mTBI) or repetitive (r-mTBI) head injury, which may differ in the potential for long term symptoms and chronic neurodegeneration. Non-invasive approaches that can detect damage and predict outcome are a high priority for clinical care of mTBI patients. Magnetic resonance (MR) diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) techniques can identify microstructural changes associated with Gaussian (DTI) and non-Gaussian (DKI) water diffusion properties. Mouse models of s-mTBI and r-mTBI targeting anterior brain regions (impact site at bregma) were developed for longitudinal MRI studies with corresponding neuropathology.

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