The objective of this ¹H MRS study was to determine the neurochemical profiles of military members with mild Traumatic Brain Injury (mTBI) and compare with age-matched, healthy military controls. Analysis of metabolite concentrations in three brain regions revealed a significant global decrease in total creatine (tCr) in mTBI subjects, as well as elevated GSH in the posterior cingulate and increased Glx in both posterior white matter and anterior cingulate regions, when compared to controls. These results could identify key biomarkers of mTBI and indicate neuroinflammatory changes and impaired brain function or integrity in mTBI.
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