Spinal cord injury (SCI)
leads to immediate sensorimotor and autonomic dysfunction and SCI patients
generally show little clinical recovery within the first year after injury.
Early structural changes at the spinal and brain level and their interactions
with recovery rate are not well understood. The aim of our study was to reveal
trauma-induced neurodegeneration and its interaction to impairment within early
stage after injury employing quantitative neuroimaging technique. Our finding
showed that significant atrophy and microstructural changes initiated in neural
sensorimotor system within already early stage after SCI and quantitative
neuroimaging methods hold potential to disclosing these neurodegeneration
mechanisms.
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