Abstract #2373

The relationship between brain white matter hyperintensities burden and age-related neuropathologies is location dependent

Chantal Sopacua¹, Arnold M. Evia¹, Aikaterini Kotrotsou¹, Sue E. Leurgans^2,3, David A. Bennett^2,3, Julie A. Schneider^2,3,4, and Konstantinos Arfanakis^1,2,5

¹Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, ²Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States, ³Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, United States, ⁴Department of Pathology, Rush University Medical Center, Chicago, IL, United States, ⁵Department of Diagnostic Radiology, Rush University Medical Center, Chicago, IL, United States

White matter hyperintensities (WMH) are white matter lesions appearing hyperintense in T2-weighted MRI. WMH are common in older adults and have been associated with increased risk of cognitive decline and dementia. Previous efforts have attempted to identify the neuropathologies associated with whole brain WMH burden. However, it is yet to be determined if the relationship between regional WMH burden and age-related neuropathologies is the same, or varies, in different parts of the brain. Therefore, the purpose of this research was to investigate the association between regional WMH burden and neuropathologies in a community cohort of older adults.

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