Abstract #2366

The mediating effects of functional disconnection on the association between structural disconnection and cognitive impairment in symptomatic carotid artery disease

Dewen Meng^1,2, Akram A Hosseini¹, Richard J Simpson^1,2, Robert A Dineen^1,2, and Dorothee P Auer^1,2

¹Radiological Sciences, Division of Clinical Neurosciences, School of Medicine, University of Nottingham, Nottingham, United Kingdom, ²Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom

This study investigated the association between functional disconnection of cognitive networks, structural disconnection indexed as microscopic damage of specific white matter tracts, and global cognitive impairment in symptomatic carotid artery disease. The findings regarding the mediating effects of functional disconnection on the association between structural disconnection and global cognitive impairment provided promising implications for future studies that develop therapies for patients with vascular cognitive disorder.

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