Abstract #2358

A Potential Biomarker of Alzheimer's Disease: T1sat of the Thalamus

Parshant Sehrawat¹, H. Michael Gach², Wenna Duan¹, Andrea Gillman³, James T. Becker⁴, Oscar L. Lopez⁵, and Weiying Dai¹

¹Department of Computer Science, State University of New York at Binghamton, Binghamton, NY, United States, ²Department of Radiation Oncology, Washington University, St Louis, MO, United States, ³Center of Neuroscience, University of Pittsburgh, PA, United States, ⁴Department of Psychology, University of Pittsburgh, PA, United States, ⁵Department of Psychiatry and Neurology, University of Pittsburgh, PA, United States

Biomarkers for Alzheimer’s disease (AD) are crucial for early diagnosis and treatment monitoring once therapies become available. In this study, the spin-lattice relaxation time in the rotating frame with (T_1sat) and without (T_1nosat) off-resonance saturation was measured at 1.5 T in the cardiovascular health study cognition study cohort. Cross-sectional and longitudinal studies of the normalized difference (ΔT_1RF) between T_1sat and T_1nosat revealed regions of statistical significance in the brain that are associated with dementia pathogenesis. ΔT_1RF changes in the thalamus were consistent for the cross-sectional and longitudinal studies, indicating that ΔT_1RF could be a promising imaging biomarker for AD.

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