Abstract #2322

Regional Brain Myelin Changes in Patients with Heart Failure

Bhaswati Roy¹, Mary Woo¹, Gregg Fonarow², Ronald M Harper^3,4, and Rajesh Kumar^4,5,6

¹UCLA School of Nursing, University of California at Los Angeles, Los Angeles, CA, United States, ²Division of Cardiology, University of California at Los Angeles, Los Angeles, CA, United States, ³Neurobiology, University of California at Los Angeles, Los Angeles, CA, United States, ⁴Brain Research Institute, University of California at Los Angeles, Los Angeles, CA, United States, ⁵Anesthesiology, University of California at Los Angeles, Los Angeles, CA, United States, ⁶Radiological Sciences, University of California at Los Angeles, Los Angeles, CA, United States

Heart Failure (HF) patients show gray matter injury in multiple brain areas, based on various MRI techniques; such injury can accompany loss of subcortical and white matter myelin integrity. However, the extent of regional myelin changes in HF is unclear. We examined regional myelin integrity in HF patients, and found decreased values, likely resulting from hypoxic/ischemic processes, in critical autonomic, cognitive, respiratory, and mood control sites. These functions are deficient in the condition. Myelin mapping, based on simple-to-calculate ratios of T1- and T2-weighted images, is useful for evaluating regional myelin changes.

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