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Abstract #2319

Brain structural MRI and perfusion signature of ALS patients with different levels of cognitive deficits

Bo Hou1, Dong-chao Shen2, Pan Peng2, Bo Cui2, Xiao-lu Li1, Hui You1, Li-zhi Xie3, Li-ying Cui2, and Feng Feng1

1Radiology, Peking Union Medical College Hospital, Beijing, People's Republic of China, 2Neurology, Peking Union Medical College Hospital, Beijing, People's Republic of China, 3Ge Healthcare, MR Research China, Beijing, People's Republic of China

This study was done to explore potential brain changes in ALS patients with different levels of cognitive deficits with voxel-based analysis of CBF generated by pCASL and VBM. Significant GM loss and CBF decrease were demonstrated in the severe frontotemporal dementia group. No difference of GM or CBF was found between ALS-Cn and ALS-Ci. Differences between ALS-Ci and ALS-FTD overlapped with those found between ALS-Cn and ALS-FTD, and the changes were more widespread in the latter contrast.

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