Abstract #2316

Quantitative evaluation of brain volume change after phthalate esters exposure using voxel-based morphometry

Ju-Chien Wu¹, Jun-Cheng Weng^1,2, Jeng-Dau Tasi³, Chao-Yu Shen^1,2,4, and Shu-Li Wang⁵

¹Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan, ²Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan, ³School of Medicine and Department of Pediatrics, Chung Shan Medical University and Hospital, Taichung, Taiwan, ⁴Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, ⁵National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan

The products made by phthalate esters could be found everywhere. But there were only a few studies mentioned about the influence of phthalate esters exposure on brain volume. We used the voxel-based morphometry analysis to observe the correlation between the concentrations of maternal urine phthalate esters (MBP, MBzP, DEHP, MEHP, MEOHP) and children’s brain volume of gray and white matter. We found the negative correlation between the concentrations and the volume of frontal gyrus and cingulate gyrus.

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