Migraine subjects were demonstrated to exhibit white matter alterations detected by diffusion tensor imaging (DTI). Due to the Gaussian assumption of water distribution employed in DTI technique, the measured diffusivity may not be accurate and may hinder the detection of white matter alterations. Diffusion kurtosis imaging (DKI) was demonstrated to better characterize white matter alterations without Gaussian assumption and has not been utilized to detect white matter alterations in migraine subjects. This study performed DKI to detect microstructural white matter alterations and demonstrated that diffusion kurtosis parameters were more sensitive to subtle white matter alterations than diffusion tensor parameters.
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