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Abstract #2301

The effect of the dopamine D4 receptor −616 C/G polymorphism on gray matter volume and functional connectivity in pediatric primary nocturnal enuresis patients

Bing Yu1, Mingzhu Huang2, Xu Zhang, Kaining Shi3, and Qiyong Guo1

1Shengjing Hospital of China Medical University, Shenyang, People's Republic of China, 2Shengjing Hospital of China Medical University, 3Philips healthcare

The study assessed the effects of (DRD4) -616 (rs747302) gene variation on gray matter volume (GMV) and arousal from sleep (AS) scores in children that suffered from primary nocturnal enuresis (PNE) and normal controls and found that The −616 C/G SNP in the DRD4 promoter may affect the AS scores and GMV in the thalamus and pregenual ACC in PNE children.

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Abstract