Abstract #2242

Remitted and non-remitted patients with schizophrenia show distinct patterns of white matter tract alterations

Jing-Ying Huang¹, Chih-Min Liu^2,3, Tzung-Jeng Hwang^2,3, Yu-Jen Chen¹, Yung-Chin Hsu¹, Hai-Gwo Hwu^2,3, and Wen-Yih Isaac Tseng^1,3,4,5

¹Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan, ²Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan, ³Graduate Institute of Brain and Mind Sciences, National Taiwan University College of Medicine, Taipei, Taiwan, ⁴Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan, ⁵Molecular Imaging Center, National Taiwan University, Taipei, Taiwan

To investigate the relations between white matter tracts and treatment outcome, we performed diffusion spectrum imaging (DSI) and whole brain tract-based automatic analysis (TBAA) comparisons of the tract integrity over the whole brain. As compared with health controls, non-remitted patients showed reduced integrity in 7 fiber tract bundles, whereas remitted patients only showed 4 fiber tract bundles. When comparing with remitted patients, non-remitted patients showed reduced integrity in the same 7 fiber tract bundles as those found in comparison with healthy controls. Our results support that remitted and non-remitted patients had distinctly different severity of tract alterations.

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