Meeting Banner
Abstract #2215

Effect of Lesion-related Signal Variation in Proton Density Reference Image on Blood Flow Quantification with Arterial Spin Labeling MRI for Differentiating Pseudo-progression from True Progression in Gliomas

Jason M Johnson1, Mu-Lan Jen2, David D Shin3, Ping Hou2, Caroline Chung4, Donald F Schomer1, and Ho-Ling Liu2

1Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, 2Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, 3Department of Radiology, University of California, San Diego, La Jolla, CA, United States, 4Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States

CBF quantification using ASL is an important MR technique for the evaluation of suspicious enhancing lesions for patients’ status post chemotherapy treatment. The quantification requires an estimate of equilibrium magnetization of blood which is often obtained using a set of proton density (PD) reference images; however, this approach can lead to errors in CBF based on tissue variation in PD which could then lead to inaccurate assessment of pseudo-progression (PsP) versus true progression (TP). Our work showed that PD variation led to a reduced diagnostic performance of CBF particularly in the region of enhancing lesions with pathologic proven TP.

This abstract and the presentation materials are available to members only; a login is required.

Join Here

Abstract