Abstract #2210

Identifying Isocitrate Dehydrogenase Genotype in Low-grade Glioma Non-invasively using Amide Proton Transfer-Weighted (APTW) Imaging

Shanshan Jiang^1,2, Charles Eberhart³, Maria Adelita Vizcaino Villalobos³, Xianlong Wang², Yu Wang⁴, Hao Yu², Tianyu Zou², Yongxing Du², Hye-Young Heo², Yi Zhang¹, Peter Van Zijl¹, Jinyuan Zhou¹, and Zhibo Wen²

¹Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Department of Radiology, Southern Medical University, Zhujiang Hospital, Guangzhou, People's Republic of China, ³Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Department of Pathology, Southern Medical University, Zhujiang Hospital, Guangzhou, People's Republic of China

We explored the radiographic features of isocitrate dehydrogenase (IDH) wildtype and mutated tumors in glioma patients preoperatively using APTW imaging at 3 Tesla. 26 patients with newly suspected low-grade gliomas were recruited, surgical specimens were obtained for pathological analysis, and corresponding APTW signal intensities were recorded. Results showed that the IDH1 wild-type tumors had significantly higher APTW signal intensity than the IDH1 mutant tumors. The area under the ROC curve (AUC) for APTW to differentiate IDH1 wild-type from IDH1 mutant was 0.750. APT imaging has the potential for discriminating IDH genotypes in WHO grade-II gliomas.

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