We show that there are observable VBM changes in white matter and grey matter fractions of an aging mouse and these changes are attenuated with a lipophilic high iron diet. This data support the hypothesis that regressive white matter degeneration may be prevented with increased access to CNS iron. Animals that do not have brain iron overloading show longitudinal white matter changes not observed in the iron loaded animals. Furthermore, our data supports the white matter retrogenesis model observed in the aging human brain.
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