Physical exercise is known to boost the spontaneous recovery, but the exact mechanism for exercise induced recovery after brain injury is not clearly known. In this study, we show enhanced neuroplasticity with physical exercise on the intact side as well as the damaged side for the HI injured rat brain by calculating the brain activation maps from BOLD-fMRI: Increased inter-hemispheric transfer and intra-hemispheric extension of activated areas were observed with physical exercise covering the widespread sensory-motor related areas in the contralesional hemisphere.
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