Whole-Tumor Quantitative Apparent Diffusion Coefficient Histogram Analysis in Differentiating intrahepatic mass-forming cholangiocarcinoma from poorly differentiated hepatocellular carcinoma

Differentiating intrahepatic mass-forming cholangiocarcinoma (IMCC) and poorly differentiated hepatocellular carcinoma(pHCC) is often difficult for radiologists, but it is important for providing appropriate treatments. In our study, we use noncontrast MRI with diffusion-weighted imaging in combination with whole-tumor quantitative apparent diffusion coefficient (ADC) histogram analysis to differentiate IMCC from pHCC. The result reveals that ADC histogram analysis based on the whole-tumor can be considered a useful and noninvasive method to help differentiate IMCC from pHCC. Especially ADC_25% of histogram analysis allows differentiation of IMCC from pHCC with higher accuracy.