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Abstract #2083

Association of breastfeeding duration with abdominal fat distribution and adipose tissue hydration at 4.5 years

Suresh Anand Sadananthan1, Wei Wei Pang2, Navin Michael1, Mya Thway Tint2, Kuan Jin Lee3, Lynette Pei-Chi Shek4, Yap Kok Peng Fabian5,6, Keith M Godfrey7, Melvin Khee-Shing Leow8,9, Yung Seng Lee1,4, Peter D Gluckman1,10, Christiani Jeyakumar Henry8, Marielle Valerie Fortier11, Yap Seng Chong1,2, and S. Sendhil Velan3

1Singapore Institute for Clinical Sciences, A*STAR, Singapore, 2Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 3Singapore BioImaging Consortium, A*STAR, Singapore, 4Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 5Department of Paediatric Endocrinology, KK Women’s and Children’s Hospital, Singapore, 6Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, 7MRC Lifecourse Epidemiology Unit & NIHR Southampton Biomedical Research Centre, University of Southampton & University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom, 8Clinical Nutrition Research Centre, Singapore Institute for Clinical Sciences, A*STAR, Singapore, 9Department of Endocrinology, Tan Tock Seng Hospital, Singapore, 10Liggins Institute, University of Auckland, Auckland, New Zealand, 11Department of Diagnostic and Interventional Imaging, KK Women’s and Children’s Hospital, Singapore

The association of the duration of breastfeeding with childhood obesity is equivocal. The first year of life is a period of hypertrophic expansion of adipocytes with little increase in adipocyte number. Hence, over-nutrition during this period could potentially result in persistent changes in adipocyte size that may last until adulthood. In this study, we have investigated the association of breastfeeding duration with abdominal fat distribution and adipose tissue cellularity at 4.5 years. Our results indicate a weak protective effect of longer breastfeeding duration on abdominal subcutaneous adipose tissue volumes and subcutaneous adipose tissue morphology.

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Abstract