We compared image quality, lesion conspicuity and diagnostic performance of calculated and acquired b1600 DW images for prostate cancer (PCa) detection and assessed the added value of calculated b2000 images for PCa detection. We showed that calculated b1600 had equivalent image quality and diagnostic performance for PCa detection compared to acquired b1600 images with improved tumor-to-PZ contrast ratio, which suggests that calculated b1600 could be an alternative to acquired b1600 to decrease acquisition time. We also showed that calculated b2000 had better tumor conspicuity than b1600.
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