Abstract #2050

Receiver operating characteristic analysis of fat-fraction is effective in differentiating identifying an optimal threshold to differentiate between brown and white adipose tissue ex vivo and in situ in rats using 3-point IDEAL MRI

Terence Jones^1,2, Narendra Reddy³, Sarah Wayte⁴, Thomas Barber^2,3, and Charles Edward Hutchinson^1,2

¹Department of Radiology, University Hospitals Coventry & Warwickshire NHS Trust, Birmingham, United Kingdom, ²Warwick Medical School, University of Warwick, Coventry, United Kingdom, ³Department of Endocrinology, University Hospitals Coventry & Warwickshire NHS Trust, Birmingham, United Kingdom, ⁴Medical Physics, University Hospitals Coventry & Warwickshire NHS Trust, Coventry, United Kingdom

Brown adipose tissue (BAT) has lower fat content than white adipose tissue (WAT), which has been exploited using Dixon-based MRI to identify BAT. We sought to identify the optimal threshold to differentiate between BAT and WAT in rats on the basis of fat fraction.

Fat fraction within BAT was significantly lower than WAT in rodents. Receiver operating characteristic analysis showed that differentiating BAT and WAT on the basis of fat fraction had excellent accuracy in both ex vivo and in situ. The optimal cut-off to separate BAT and WAT was significantly lower in rats exposed to cold, likely secondary to lipolysis.

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