Abstract #2019

Liver Iron Concentration determined by Gradient Echo MRI using Signal Intensity Ratios: Impact of Acquisition Parameters and Image Quality

Arthur Peter Wunderlich^1,2, Holger Cario³, Isabelle Tomczak¹, Meinrad Beer¹, and Stefan Andreas Schmidt¹

¹Diagnostic and Interventional Radiology, Ulm University, Medical Center, Ulm, Germany, ²Section for Experimental Radiology, Ulm University, Medical Center, Ulm, Germany, ³Department of Pediatrics and Adolescent Medicine, Ulm University, Medical Center, Ulm, Germany

Tissue signal intensity ratio (SIR) has been used for a long time to determine liver iron concentration (LIC) based on gradient echo MRI. We studied the influence of acquisition parameters FA, RF spoiling and saturation regions, as well as image quality score, on the correlation of natural logarithm of SIR values to reference LIC obtained with spin echo. In our cohort of 85 patients, no significant influence on the slope of linear regression line was found, neither of acquisition protocol settings nor image quality, whereas the intercept was dependent on parameters influencing T₁ sensitivity, namely FA and RF spoiling.

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