Depending on the difference of cellular densities related to the histopathologic grades of HCCs, some investigators have recently suggested apparent diffusion coefficient (ADC) on diffusion-weighted imaging (DWI) as an effective biomarker for the prediction of the patients’ prognosis before the treatment of HCC. In the present study, ADCs of well- or poorly differentiated HCCs were lower than moderately differentiated HCCs; meanwhile the degree of arterial phase enhancement during the dynamic imaging rather well stratified the ADCs of the lesions. We concluded that ADC could not be independently used to estimate the histopathologic grades of HCCs.
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