Abstract #1993

Spectroscopy-Based R2 Relaxometry for Liver Iron Quantification at 1.5T and 3.0T

Diego Hernando^1,2, Changqing Wang^1,3,4, Ryan J. Mattison⁵, Takeshi Yokoo^6,7, and Scott B. Reeder^1,2,8,9,10

¹Radiology, University of Wisconsin-Madison, Madison, WI, United States, ²Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ³School of Automation Engineering, University of Electronic Science and Technology of China, Chengdu, People's Republic of China, ⁴School of Biomedical Engineering and Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, Guangzhou, People's Republic of China, ⁵Medicine, University of Wisconsin School of Medicine and Public Health, WI, United States, ⁶Radiology, University of Texas-Southwestern, Dallas, TX, United States, ⁷Advanced Imaging Research Center, University of Texas-Southwestern, Dallas, TX, United States, ⁸Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ⁹Medicine, University of Wisconsin-Madison, Madison, WI, United States, ¹⁰Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States

R2-based techniques for liver iron quantification using Spin-Echo (SE) imaging require long acquisitions. In contrast, single-voxel Stimulated-Echo Acquisition Mode (STEAM)-MR spectroscopy enables liver R2 measurements in a single breath-hold. However, the accuracy and field strength dependence of STEAM-MRS R2 quantification are unknown. This study evaluated the accuracy and field strength dependence of STEAM-MRS for R2 quantification in healthy controls and patients with liver iron overload. At 1.5T, STEAM-MRS R2 was in close agreement with SE-MRI-based R2. Further, STEAM-MRS R2 measurements were highly correlated across field strengths. Finally, STEAM-MRS R2 measurements at 1.5T and 3.0T were calibrated to liver iron concentration.

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