Abstract #1988

Towards Eliminating Magnetization Transfer (MT) Effect on CEST Quantification Using MR Fingerprinting: Simulations

Pei Han^1,2, Zhengwei Zhou^3,4, Kui Ying^1,2, and Debiao Li^3,4,5

¹Department of Engineering Physics, Tsinghua University, Beijing, People's Republic of China, ²Key Laboratory of Particle and Radiation Imaging, Ministry of Education, Beijing, People's Republic of China, ³Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ⁴Department of Bioengineering, University of California Los Angeles, Los Angeles, CA, United States, ⁵Department of Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, United States

In this work, a new quantitative chemical exchange saturation transfer (q-CEST) method based on MR fingerprinting is developed to eliminate the influence of MT effect. Signal evolutions are generated by using a series of hard saturation pulses with different amplitudes and durations. The dictionary is constructed using the 2-pool model. Simulation experiments based on the 3-pool model were performed, and simulation results show that good mapping accuracy was achieved even in the presence of the MT effect.

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