Despite its importance, T1 relaxation in brain and spinal cord is not well understood. The Four Pool Model gives a fundamental framework for its understanding in white and grey matter tissue. In this work, we characterize the Four Pool Model for the first time in formalin-fixed sheep's brain using NMR spectroscopy. We find this is a suitable system, and our results are consistent with previous studies: T1 is multi-exponential and the values measured result from a convolution of pure relaxation and exchange processes.
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