Abstract #1924

Accurate Tissue Oxygen Level-dependent MRI with true T1-weighted signal

SoHyun Han¹, HyungJoon Cho², and Seong-Gi Kim^1,3

¹Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon, Korea, Republic of, ²Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of, ³Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of

Tissue oxygen level dependent (TOLD) MRI utilizes that T₁ is directly related with tissue pO₂. TOLD MRI is acquired by gradient echo based with a minimized TE. However, T₂^* contribution may not fully be suppressed. Here, we investigated the modulations of longitudinal and transverse relaxation times with oxygen challenge (OC) and compared TOLD signals from FLASH, UTE, and TSE at 7 T and 15.2 T. At both magnetic fields, T₂ did not change with tissue pO₂ while T₁ did. Spin echo and UTE appear to reflect true pO₂ levels due to invariability in T₂ during OC and minimized T₂^* with ultrashort TE, respectively.

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