A method for noninvasive assessment of mouse glomerular filtration rate (GFR) using dynamic contrast enhanced MRI (DCE-MRI) was developed and validated. The kinetics of gadolinium in the abdominal aorta and two kidneys were measured using a snapshot fast low angle shot based T1 mapping method with a temporal resolution of 1 s. A modified bi-compartmental model was used for quantification of GFR by a least-squares fitting. As a reference standard, GFR was also measured using FITC-inulin clearance. Single-kidney GFR measured from both methods showed a good agreement, suggesting the proposed DCE-MRI method provides an accurate measurement of murine single-kidney GFR.
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