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Abstract #1891

Validation of quantitative pre-clinical pseudo-continuous ASL in rat brain

Manon A. Simard1, James R. Larkin1, Alexandre A. Khrapitchev1, James A. Meakin2, Thomas W. Okell2, Peter Jezzard2, Michael A. Chappell3, and Nicola R. Sibson1

1CRUK and MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom, 2FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 3Institute of Biomedical Engineering, Department of Engineering, University of Oxford, Oxford, United Kingdom

Guidelines for pre-clinical ASL are lacking. We propose MRI parameters for the use of pseudo-continuous ASL in rats. Carotid artery velocity was determined in three rat strains. Bloch simulations for ASL with this information and with parameters for pre-clinical scanners were used to determine the optimal width of the tagging plane required for blood inversion in this smaller species. The use of multiple post-label delays (PLD) in ASL-MRI generated blood arrival maps indicating that a PLD of 550ms was sufficient. Validation of CBF maps generated from ASL was performed using autoradiography, the current gold-standard technique for pre-clinical perfusion measurement.

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