A novel PVC algorithm using Multi-TI ASL, acquiring ASL images at multiple PLDs, has been proposed to estimate CBF and ATT in GM and WM separately. A 3D kernel was used to reduce noise sensitivity and improve the estimation power. The proposed method successfully estimated four perfusion parameters (GM CBF, GM ATT, WM CBF, and WM ATT) simultaneously, and may allow region- or voxel-based perfusion analyses in WM, as well as GM.
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