Abstract #1862

Exploring Cortical Fiber Crossings in Mice using Diffusional Kurtosis Imaging

Emilie T McKinnon^1,2,3, Jens H Jensen^1,2, G Russell Glenn^2,4, Andy Y Shih^2,4, and Joseph A Helpern^1,2,3,4

¹Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, United States, ²Center for Biomedical Imaging, Medical University of South Carolina, Charleston, SC, United States, ³Department of Neurology, Medical University of South Carolina, Charleston, SC, United States, ⁴Department of Neuroscience, Medical University of South Carolina, Charleston, SC, United States

The ability of diffusional kurtosis imaging (DKI) to detect multiple intravoxel fiber directions in vivo is demonstrated for mouse cortex, with two or more directions being detected in the majority of voxels. The distribution of angular differences between the different fiber directions for individual voxels peaked at near 90^o, suggestive of a grid-like pattern of neurites. Our findings support the feasibility of DKI-based tractography in mouse cortex.

This abstract and the presentation materials are available to members only; a login is required.

Join Here