Abstract #1847

Investigation of Diffusion Tensor Indices by ROI analysis and TBSS of Patients with Depressive Symptoms in the Elderly with Dementia

Tsung-Yuan Li^1,2, Ni-Jung Chang¹, Clayton Chi-Chang Chen^1,3, and Jyh-Wen Chai^1,3,4

¹Department of Radiology, Taichung Veterans General Hospital, Taichung, Taiwan, Taichung, Taiwan, ²Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan, Taichung, Taiwan, ³Department of Biomedical Engineering, HungKuang University, Taichung, Taiwan, Taichung, Taiwan, ⁴College of Medicine, China Medical University, Taichung, Taiwan, Taichung, Taiwan

The differences of indices in diffusion tensor images (DTI) of patients with dementia are well-discussed in recent years. However, the comorbidity of dementia and depression was observed. In this study, we focused on the white matter changes associated with depressive symptoms in dementia and the relationship between DTI indices and cognitive functions in depressed and non-depressed patients. By an ROI-based analysis of the indices and TBSS analysis in DTI, we investigated the differences between patients of dementia with depression and without depression. Furthermore, we correlate the differences with the score of some clinical cognitive test to figure out the subtle differences.

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