Abstract #1833

Comparaison of in vivo and ex vivo high resolution imaging of the mouse brain at 11.7T

Sophie Bernadette Sébille^1,2, Isaac Adanyeguh^1,2, Elise Marsan², Sirenia Lizbeth Mondragon-Gonzalez^2,3, Fatma Gargouri^1,2, and Mathieu David Santin^1,2

¹Center of NeuroImaging Research - CENIR, Paris, France, ²Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Paris, France, ³Behavior, Emotion and Basal Ganglia (BEBG), Brain and Spine Institute, Paris, France

This study compares high resolution in vivo and ex vivo diffusion imaging of mouse brain at 11.7T. The study shows that even with the advancement in image sequences and equipment, ex vivo imaging remains superior to in vivo imaging in terms of resolution with clear delineation of brain structures. However, fractional anisotropy values obtained from ex vivo imaging may not be a true representation of the in vivo condition. Nonetheless, the resolution obtained from in vivo imaging should allow for longitudinal studies.

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