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Abstract #1791

Novel application of the reversed gradient method in Diffusion Weighted-MRI for tumor response assessment in head and neck squamous cell carcinoma patient undergoing radiation therapy.

David Aramburu Nuñez1,2,3, Jose Luis del Olmo Claudio3, Silvia Reigosa Montes3, Antonio López Medina3, Moises Mera Iglesias4, Francisco Salvador Gómez 3, Íñigo Nieto5, Alfonso Calzado2, Amita Shukla-Dave6, and Victor M Muñoz5

1Medical Physics, Memorial Sloan-Kettering Cancer Center, NEW YORK, NY, United States, 2Department of Radiology, Complutense University, MADRID, Spain, 3Department of Medical Physics and Radiological protection, Galaria - Hospital do Meixoeiro – Complexo Hospitalario Universitario de Vigo, VIGO, Spain, 4Medical Physics, Oncoserv, Santiago de los Caballeros – Dominican Republic, Dominican Republic, 5Department of Radiation Oncology, Galaria - Hospital do Meixoeiro – Complexo Hospitalario Universitario de Vigo, Spain, 6Departments of Medical Physics & Radiology, Memorial Sloan-Kettering Cancer Center, NY, United States

Reversed gradient method can reduce geometric distortion leading to accurate measurement of ADC. We designed a new phantom for distortion assessment and tested the reversed gradient method in both phantom and head and neck cancer patients, obtaining a relevant increase in mutual information values (phantom: 13% – 35%; patients: 6% - 100%). The voxel-wise analysis of the tumor showing variation of ADC with treatment exhibits significant difference (p<0.01) in calculated ADC between corrected and raw images. In future studies, the reverse gradient method may be included as part of clinical DW-MRI that focus on tumor response assessment.

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