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Abstract #1772

Changes of non-Gaussian diffusion MRI parameters at different diffusion times in a human breast carcinoma xenograft model

Mami Iima1,2, Tomomi Nobashi3, Hirohiko Imai4, Sho Koyasu5, Akira Yamamoto1, Masako Kataoka1, Yuji Nakamoto1, Tetsuya Matsuda6, and Kaori Togashi1

1Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 2Hakubi Center for Advaned Research, Kyoto University, Kyoto, Japan, 3Graduate Schoolof Medicine, Kyoto University, Kyoto, Japan, 4Research and Educational Unit of Leaders for Integrated Medical System, Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Kyoto, Japan, 5Radiation Biology Center, Kyoto University, Kyoto, Japan, 6Department of Systems Sciece, Graduate School of Informatics, Kyoto University, Kyoto, Japan

The relationship between diffusion time and diffusion parameters obtained from 7.0T MRI using a human breast carcinoma xenograft model was investigated. There was an increase in K values and decrease in ADCo as well as sADC values in 27.6ms compared to 9.6 ms. Some tumor showed heterogeneous sADC change derived from two different diffusion times.

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