Abstract #1727

Relationship between GABA and glutamate and inter- and intra-regional intrinsic connectivity as measured by resting-state fMRI

Sarina J Iwabuchi^1,2, Felix Raschke³, Lena Palaniyappan^4,5, and Dorothee P Auer^1,2

¹Radiological Sciences, Division of Clinical Neuroscience, University of Nottingham, Nottingham, United Kingdom, ²Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, ³Department of Radiotherapy and Radiation Oncology, OncoRay National Center for Radiation Research in Oncology, Dresden, Germany, ⁴Departments of Psychiatry and Medical Biophysics & Robarts Research Institute, Western University, London, ON, Canada, ⁵Lawson Health Research Institute, London, ON

Associations between GABAergic and glutamatergic systems and measures of brain connectivity have been reported previously. However, there is currently no evidence for associations between these systems and local connectivity measures, limiting our understanding of inhibitory/excitatory balance and connectivity across differing spatial ranges. We demonstrated that only regional connectivity and spontaneous activity, but not long-range connectivity, were associated with GABA and GABA/Glx ratio in the ACC. We suggest that this correlation between measures of intra-regional connectivity and GABA in the ACC may be driven by interneuron activity. Further, associations between neurotransmitter pools and inter-regional connectivity may be region/network and context-specific.

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