Abstract #1721

Modulation of Saslience Network Activation after 4 Weeks Verbal Training in Older Adults

Toshiharu Nakai^1,2, Ayuko Tanaka^3,4, Mika Ueno¹, Atsunobu Suzuki⁵, and Sachiko Kiyama^4,6

¹NeuroImaging & Informatics, NCGG, Ohbu, Japan, ²Department of Radiological Science, Nagoya University Graduate School of Medicine, Nagoya, Japan, ³Faculty of Human Sciences, Kobe Shoin Women's University, Kobe, Japan, ⁴NeuroImaging & Informatics, National Center for Geriatrics & Gerontology, Ohbu, Japan, ⁵Department of Social and Human Environment, Graduate School of Environmental Studies, Nagoya, Japan, ⁶College of Liberal Arts and Sciences, Mie University, Tsu, Japan

The potential of RSN to detect the early change of neuronal networks induced by short-term cognitive intervention was investigated by using a verbal training task to read short sentences aloud everyday for 4 weeks. Twenty community dwelling older adults participated in this study. Activation in the anterior SN was decreased after the training, suggesting optimization of salience processing to integrate visual information and language production. The SN may be potentially a biomarker to firstly reflect the change in response to cognitive interventions in older adults and this finding may be applied to optimize training protocols for each individual.

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