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Abstract #1718

Enhanced striatum connectivity is irrelevant to baseline perfusion in major depressive disorder following sertraline treatment

Changwei W. Wu1,2, Zi-Xuan Chang3, I-Ling Chung4, Chien-Yuan Lin5, Ching-Po Lin6, Chi-Bin Yeh7, and Hong-Wen Kao4

1Graduate Institute of Humanities in Medicine, Taipei Medical University, Taipei, Taiwan, 2Brain and Consciousness Research Center, Taipei Medical University, Taipei, Taiwan, 3Department of Biomedical Sciences and Engineering, National Central University, Taoyuan, Taiwan, 4Department of Radiology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, 5GE Healthcare, Taipei, Taiwan, 6Institute of Neuroscience, National Yang-Ming University, Taipei, Taiwan, 7Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan

We revisited the sertraline treatment effect on RSFC in drug-naïve MDD patients and evaluated the association between RSFC, ALFF and baseline CBF level. Twenty-four unmedicated MDD subjects were recruited and treated with sertraline for 6 weeks. Results showed negative correlation between HAM-D scores and striatum-MPFC RSFC. However, the therapeutic effect on RSFC was irrelevant to the CBF or ALFF levels, implying better temporal synchronizations from the neural basis.

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Abstract