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Abstract #1705

Resting state fMRI in Patients Infected with Hepatitis C Virus

Santosh Kumar Yadav1, Ajay Vardaan2, Rakesh Kumar Gupta3, Pradeep Kumar Gupta3, Samir Mohindra4, Deepak Kaura5, Francesco Marincola1, Ena Wang1, and Mohammad Haris1

1Research Department, Sidra Medical and Research Center, Doha, Qatar, 2Department of Medicine, King George Medical University, Lucknow, India, 3Department of Radiology and Imaging, Fortis Memorial Research Institute, India, 4Department of Gastroenterology, Sanjay Gandhi Post graduate Institute of Medical Science, India, 5Department of Radiology, Sidra Medical and Research Center, Doha, Qatar

Current study measured the amplitude of low-frequency fluctuations (ALFF) and insular functional connectivity (FC) in Hepatitis C virus patients and compared with age and gender matched control using RESTplus software. HCV patients showed significantly reduced ALFF in the right insula. The right insular FC strength was lower in patients than control. Neuropsychological test scores were significantly lower in HCV patients. Changes in ALFF and FC provide new evidences of altered neuronal activity in HCV patients.

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