Abstract #1698

Resting State Brain Networks in Perinatally HIV-infected Adult Youths

Manoj K Sarma¹, Bharat Biswal², Margaret A Keller³, Tamara Welikson⁴, Irwin Walot⁵, David E Michalik⁶, Karin Nielsen-Saines⁷, Jaime Deville⁷, Andrea Kovacs⁸, Eva Operskalski⁸, Joseph Ventura⁹, and M. Albert Thomas¹

¹Radiological Sciences, UCLA School of Medicine, Los Angeles, CA, United States, ²Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, United States, ³Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, United States, ⁴Semel Institute for Neuroscience and Human Behavior, UCLA School of Medicine, Los Angeles, CA, United States, ⁵Radiology, Harbor-UCLA Medical Center, Torrance, CA, United States, ⁶Infectious disease-Pediatrics, Miller Children's Hospital, Long Beach, CA, United States, ⁷Pediatrics, UCLA School of Medicine, Los Angeles, CA, United States, ⁸Pediatrics, Keck School of Medicine of USC, Los Angeles, CA, United States, ⁹Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, CA, United States

Youths with perinatally infected HIV survive longer with combination antiretroviral therapy, but remain at risk for poor cognitive outcomes. Since changes in cognitive function may be preceded by subtle changes in brain function, resting-state functional magnetic resonance imaging (rs-fMRI) may become useful in evaluating functional connectivity in these youths. We evaluated alterations in brain functional connectivity in eight perinatally HIV-infected youths and eleven healthy controls. Results from this study demonstrate that, compared to normal subjects, the strength of the several networks connectivity including DMN, Dorsal Attention, Lateral Visual, were significantly decreased in several regions among perinatally HIV-infected youth. The detailed mechanisms, implications of these brain activities and networks exhibiting changes will require further investigation.

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