Abstract #1691

Connectivity of the Default Mode Network – Prior and post an oddball paradigm

Irene Neuner^1,2,3,4, Ravichandran Rajkumar^1,2,3,4, Shukti Ramkiran¹, Tracy Warbrick¹, Jorge Arrubla¹, and N Jon Shah^1,3,4,5,6

¹Institute of Neuroscience and Medicine 4 (INM4), Forschungszentrum Juelich GmbH, Juelich, Germany, ²Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany, ³JARA – BRAIN – Translational Medicine, Juelich, Germany, ⁴TRIMAGE-consortium, Juelich, Germany, ⁵Department of Neurology, RWTH Aachen University, Aachen, Germany, ⁶Department of Electrical and Computer Systems Engineering, and Monash Biomedical Imaging, School of Psychological Sciences, Monash University, Melbourne, Australia

The DMN is shown to be highly active during resting state and is rapidly deactivated during externally directed tasks. However, it is unclear how demanding the task needs to be to switch the DMN out of the resting state mode. Aiming to answer this question we chose a visual oddball paradigm and assessed the functional connectivity of the DMN during resting state in a rest-task-rest design. The oddball paradigm demands very little cognitive resources and therefore we hypothesize that the DMN will not be altered in its connectivity pattern during post task resting state.

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