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Abstract #1678

Differential effects of anesthetics on mouse brain connectivity and function as probed by resting-state fMRI and [18]FDG-PET

Meltem Karatas1,2,3,4, Laetitia Degiorgis1, Marion Sourty1, Daniel Roquet1, Lionel Thomas5, Patrice Marchand5, Thomas Bienert3, Lee Hsu-Lei3, Julien Lamy1, Chrystelle Po1, Frédéric Boisson5, David Brasse5, Dominik von Elverfeldt3, Izzie Jacques Namer1,6, Jean-Paul Armspach1, Ipek Yalcin2, and Laura-Adela Harsan1,3,6,7

1ICube, CNRS, University of Strasbourg, Strasbourg, France, 2INCI, CNRS, University of Strasbourg, Strasbourg, France, 3Department of Radiology, Medical Physics, University Medical Center Freiburg, Freiburg, Germany, 4Faculty of Biology, University of Freiburg, Freiburg, Germany, 5IPHC, CNRS, University of Strasbourg, Strasbourg, France, 6Engineering Science, Computer Science, and Imaging Laboratory, Integrative Multimodal Imaging in Healthcare, CNRS, University of Strasbourg, Strasbourg, France, Strasbourg, France, 7Department of Biophysics and Nuclear Medicine, University Hospital Strasbourg, Strasbourg, France

Mice resting state functional connectivity (FC) studies are highly attractive given the large number of existing murine models of neuropsychiatric disorders. Currently, most of mouse rs-fMRI studies are carried out under anesthesia, to limit motion and animal distress. Yet, anesthetics affect brain FC. Currently, no reliable awake mouse brain FC reference is available. We compared mouse brain rs-fMRI patterns under medetomidine or isoflurane anesthesia and paralleled the experiments with static 18FDG-PET exams, where the tracer biodistributions occurred under isoflurane, medetomidine anesthesia or in conscious state, reflecting the brain glucose metabolism, as indirect measures of neuronal activity.

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