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Abstract #1672

Frequency-dependent hemodynamic response to somatosensory stimulation in ketamine-anesthetized mice

Hyun-Ji Shim1,2, Joonsung Lee1, Jungryun Lee1, Jeong Pyo Son1,2, Won Beom Jung1,3, Sangwoo Kim1, and Seong-Gi Kim1,2,3

1Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon, Korea, Republic of, 2Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan Universiy, Suwon, Korea, Republic of, 3Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of

Optimizing parameters of electrical forepaw stimulation is necessary to investigate biophysical and molecular properties of fMRI signals. However stimulation parameters and anesthesia in mice are not well-defined. Here we introduced ketamine anesthesia in mice. Initially, forepaw stimulation frequency was refined with for CBV-weighted OIS experiments. To translate electrical stimulation parameters from OIS into BOLD fMRI, we tested two stimulation frequencies. Application of our sensory stimulus parameters evoked well-localized and robust BOLD fMRI signals in ketamine anesthetized mice.

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