Abstract #1657

Quantifying the dynamics of cerebral blood flow, oxygen metabolism, and deoxygenated blood volume with a combined normoxia/hyperoxia method

Eulanca Y. Liu^1,2,3, Frank Haist^4,5, David J. Dubowitz^3,6, and Richard B. Buxton^3,6

¹Neurosciences Graduate Program, University of California, San Diego, La Jolla, CA, United States, ²Medical Scientist Training Program, University of California, San Diego, La Jolla, CA, United States, ³Center for Functional MRI, University of California, San Diego, La Jolla, CA, United States, ⁴Psychiatry, University of California, San Diego, ⁵Center for Human Development, University of California, San Diego, ⁶Radiology, University of California, San Diego

To better understand the dynamics of the BOLD response in terms of CBF, CMRO₂, and deoxygenated blood volume, we used a combined normoxia/hyperoxia approach to untangle their relative contributions. This method was applied to both the positive activation response and the post-stimulus undershoot, the origins of which are still debated. A simple model of the BOLD response based on flow, metabolism, and volume, modified to include the effects of hyperoxia, was applied. For the origin of the undershoot, these data provide strong evidence for a CBF undershoot, moderate evidence for elevated CMRO₂, and no evidence for elevated CBV (Balloon Model).

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