Resting state fMRI is prone to a large range of factors affecting the acquired data and processing pipelines available, which can impact on the outcome of a study. This study assessed the similarity of time series taken from aCompCor outputs to global signal to assess the inclusion of a ‘proxy’ global signal and its effect on group-wise tests of default-mode connectivity. The first components of both white matter and CSF were highly correlated with global signal and regressing either global signal or aCompCor outputs altered group-comparisons of functional connectivity. Future studies should scrutinise and report their postprocessing pipelines clearly.
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